Widespread distribution of cell defense against D-aminoacyl-tRNAs.

@article{Wydau2009WidespreadDO,
  title={Widespread distribution of cell defense against D-aminoacyl-tRNAs.},
  author={Sandra Wydau and Guillaume van der Rest and Caroline Aubard and Pierre Plateau and Sylvain Blanquet},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 21},
  pages={14096-104}
}
Several l-aminoacyl-tRNA synthetases can transfer a d-amino acid onto their cognate tRNA(s). This harmful reaction is counteracted by the enzyme d-aminoacyl-tRNA deacylase. Two distinct deacylases were already identified in bacteria (DTD1) and in archaea (DTD2), respectively. Evidence was given that DTD1 homologs also exist in nearly all eukaryotes, whereas DTD2 homologs occur in plants. On the other hand, several bacteria, including most cyanobacteria, lack genes encoding a DTD1 homolog. Here… CONTINUE READING

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