Widespread demyelination in the cerebellar cortex in multiple sclerosis.

  title={Widespread demyelination in the cerebellar cortex in multiple sclerosis.},
  author={Alexandra Kutzelnigg and Jens C Faber-Rod and Jan Niklas Bauer and C F Lucchinetti and Per Soelberg Sorensen and Henning Laursen and Christine Stadelmann and Wolfgang Br{\"u}ck and Helmut Rauschka and Manfred Schmidbauer and Hans Lassmann},
  journal={Brain pathology},
  volume={17 1},
Neocortical demyelination in the forebrain has recently been identified as an important pathological feature of multiple sclerosis (MS). Here we describe that the cerebellar cortex is a major predilection site for demyelination, in particular in patients with primary and secondary progressive MS. In these patients, on average, 38.7% of cerebellar cortical area is affected, reaching in extreme examples up to 92%. Cerebellar cortical demyelination occurs mainly in a band-like manner, affecting… CONTINUE READING
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