Widespread defects in the primary olfactory pathway caused by loss of Mash1 function.

@article{Murray2003WidespreadDI,
  title={Widespread defects in the primary olfactory pathway caused by loss of Mash1 function.},
  author={Richard C. Murray and Daniel Navi and John Fesenko and Arthur D. Lander and Anne L. Calof},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 5},
  pages={1769-80}
}
MASH1, a basic helix-loop-helix transcription factor, is widely expressed by neuronal progenitors in the CNS and PNS, suggesting that it plays a role in the development of many neural regions. However, in mice lacking a functional Mash1 gene, major alterations have been reported in only a few neuronal populations; among these is a generalized loss of olfactory receptor neurons of the olfactory epithelium. Here, we use a transgenic reporter mouse line, in which the cell bodies and growing axons… CONTINUE READING
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