Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease.

@article{Fujita2006WidespreadDO,
  title={Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease.},
  author={Masahiro Fujita and Masanori Ichise and Sami S. Zoghbi and Jeih-San Liow and Subroto Ghose and Douglass C. Vines and Janet L Sangare and Jian-qiang Lu and Vanessa L. Cropley and Hidehiro Iida and Kyeong Min Kim and Robert M. Cohen and William Bara-Jimenez and Bernard M. Ravina and Robert B. Innis},
  journal={Annals of neurology},
  year={2006},
  volume={59 1},
  pages={174-7}
}
OBJECTIVE Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. METHODS Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [(123)I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine… CONTINUE READING

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