Widespread chromosomal abnormalities in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS.

@article{Moore1999WidespreadCA,
  title={Widespread chromosomal abnormalities in high-grade ductal carcinoma in situ of the breast. Comparative genomic hybridization study of pure high-grade DCIS.},
  author={Emily S. Moore and H. Melissa Magee and John D Coyne and Tom F. Gorey and Peter A. Dervan},
  journal={The Journal of pathology},
  year={1999},
  volume={187 4},
  pages={403-9}
}
For a variety of technical reasons it is rarely possible to study cytogenetic abnormalities in ductal carcinoma in situ (DCIS) using traditional techniques. However, by combining molecular biology and computerized image analysis it is possible to carry out cytogenetic analyses on formalin-fixed, paraffin-embedded tissue, using comparative genomic hybridization (CGH). The purpose of this study was to identify the prevalence of chromosomal amplifications and deletions in high-grade DCIS and to… CONTINUE READING

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