Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition.

@article{Kronja2014WidespreadCI,
  title={Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition.},
  author={Iva Kronja and Bingbing Yuan and Stephen W Eichhorn and Kristina Dzeyk and Jeroen Krijgsveld and David P. Bartel and Terry L Orr-Weaver},
  journal={Cell reports},
  year={2014},
  volume={7 5},
  pages={1495-1508}
}
The oocyte-to-embryo transition marks the onset of development. The initial phase of this profound change from the differentiated oocyte to the totipotent embryo occurs in the absence of both transcription and mRNA degradation. Here we combine global polysome profiling, ribosome-footprint profiling, and quantitative mass spectrometry in a comprehensive approach to delineate the translational and proteomic changes that occur during this important transition in Drosophila. Our results show that… CONTINUE READING
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