Widespread changes in protein synthesis induced by microRNAs

@article{Selbach2008WidespreadCI,
  title={Widespread changes in protein synthesis induced by microRNAs},
  author={Matthias Selbach and Bjoern Schwanhaeusser and Nadine Thierfelder and Zhuo Fang and Raya Khanin and Nikolaus Rajewsky},
  journal={Nature},
  year={2008},
  volume={455},
  pages={58-63}
}
Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale. We used a new proteomic approach to measure changes in synthesis of several thousand proteins in response to miRNA transfection or endogenous miRNA knockdown. In parallel, we quantified mRNA levels using microarrays. Here we show that a single miRNA can repress the… CONTINUE READING
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