Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging

@article{Shafer2008WidespreadRT,
  title={Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging},
  author={Orie Thomas Shafer and Dong Jo Kim and Richard Dunbar-Yaffe and Viacheslav O Nikolaev and Martin J. Lohse and Paul H Taghert},
  journal={Neuron},
  year={2008},
  volume={58},
  pages={223-237}
}
The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps maintain circadian activity rhythms by coordinating a network of approximately 150 neuronal clocks. Whether PDF acts directly on elements of this neural network remains unknown. We address this question by adapting Epac1-camps, a genetically encoded cAMP FRET sensor, for use in the living brain. We find that a subset of the PDF-expressing neurons respond to PDF with long-lasting cAMP increases and confirm that… CONTINUE READING
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