Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia

@inproceedings{Blair2013WidespreadDH,
  title={Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia},
  author={John D. Blair and Ryan K. C. Yuen and Brendan K. Lim and D. E. Mcfadden and Peter von Dadelszen and Wendy P. Robinson},
  booktitle={Molecular human reproduction},
  year={2013}
}
Pre-eclampsia is a serious complication of pregnancy that can affect both maternal and fetal outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is associated with altered physiological characteristics and gene expression in the placenta. DNA methylation is a relatively stable epigenetic modification to DNA that can reflect gene expression, and can provide insight into the mechanisms underlying such expression changes. This case-control study focused on DNA… CONTINUE READING

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