Usefulness of epoxides and aziridines in synthesis
- D. M. Hodgson, P. G. Humphreys, J. G. Ward
- Org. Lett. 8,
Epoxides and aziridines are common intermediates in synthesis. Readily accessible in enantioenriched form, they are typically used as electrophiles, taking advantage of their predictable highly regioselective ring-opening reactions. Our work in the area of α-lithiated terminal epoxides and aziridines indicates that there are many other less conventional but useful reactions of these small-ring heterocycles .