Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1.

@article{Landry2002WidelySA,
  title={Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1.},
  author={Josette Ren{\'e}e Landry and Dixie L. Mager},
  journal={Genomics},
  year={2002},
  volume={80 5},
  pages={499-508}
}
Mutations in the gene MID1 are responsible for the X-linked form of Opitz syndrome, a genetic disorder that primarily affects the development of midline structures. Several mRNA isoforms with variant 5' ends have been reported for MID1, suggesting the presence of alternative transcription initiation sites. However, the genomic organization and expression pattern of the heterogeneous MID1 5'-untranslated regions (UTRs), as well as the promoter regions regulating their transcription, have not… CONTINUE READING
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