Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.

@article{Franklin1997WidelyDP,
  title={Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.},
  author={Wilbur A. Franklin and Adi F. Gazdar and Jeanette Haney and Ignacio I. Wistuba and Francisco G. La Rosa and Thomas E. Kennedy and Donna M. Ritchey and York E. Miller},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 8},
  pages={2133-7}
}
Individuals with one aerodigestive tract malignancy have a high incidence of second primary aerodigestive tumors. The mechanism for this field effect has not been determined. We studied an individual with widespread dysplastic changes in the respiratory epithelium but no overt carcinoma. The entire tracheobronchial tree obtained at autopsy was embedded in paraffin, and bronchial epithelial cells were isolated by microdissection. DNA extracted from the microdissected cells was analyzed for point… CONTINUE READING