Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence.

  title={Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence.},
  author={Rita Rubin},
  • R. Rubin
  • Published 23 July 2019
  • Medicine
  • JAMA

Update on vitamin C administration in critical illness

The effect of intravenous vitamin C in critically ill patients has yet to be determined and might be dose-dependent, but clinical studies of very high or mega doses of vitamin C are justified by preclinical data.

What Is the Role of Steroids for Septic Shock in 2021?

There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response, and there are also new frontiers for the use of corticosteroids in septic shock which should be explored in future studies.

Attention to Immortal Time Bias in Critical Care Research.

A novel checklist is presented to help readers assess the features of study design, analysis, and reporting that introduce immortal time bias or obscure its presence and it is recommended that commonly used tools designed to evaluate observational research studies should include an ITB assessment.

Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock.

Administration of hydrocortisone, high-dose ascorbic acid, and thiamine (HAT therapy) among US adults with septic shock before and after publication of a single-center study is described and outcomes between patients who received, and did not receive, HAT therapy are compared.

Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how.

Evidence from high-quality research is still insufficient to support the use of vitamin C, thiamine, and vitamin D as metabolic support in sepsis treatment.

Sepsis: Diagnosis and Management.

Fluid resuscitation is the priority in early management, including administering an intravenous crystalloid at 30 mL per kg within the first three hours, and antimicrobial therapy should be initiated early.

Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out?

Preliminary data suggests that therapy with hydrocortisone, ascorbic acid and thiamine improves the outcome of patients with sepsis with the potential to save millions of lives.

The role of steroids in severe CAP

S steroids were deleterious in influenza pneumonia and in patients with pneumococcal pneumonia data suggest a lack of efficacy and potential harm, and both European and American guidelines recommend not using corticosteroids in CAP.

Vitamin C: an essential "stress hormone" during sepsis.

  • P. Marik
  • Biology
    Journal of thoracic disease
  • 2020
Treatment with vitamin C appears to restore the stress response and improve the survival of stressed humans.

Vitamin C in surgical sepsis.

While there is promising animal and burn-related data on improved fluid resuscitation with the use of vitamin C as an adjunct, the most recent meta-analyses of the available data fail to show a survival benefit in sepsis, and concerns regarding nephrotoxicity remain.