Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells.

@article{Kang2012WiddrolIA,
  title={Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells.},
  author={Moo Rim Kang and Song-Kyu Park and Chang Woo Lee and Ig Jun Cho and Yeong Nang Jo and Jeong Wook Yang and Jin-ah Kim and Jieun Yun and Ki Hoon Lee and Hyun Ju Kwon and Byung Woo Kim and Kiho Lee and Jong Soon Kang and Hwan Mook Kim},
  journal={Oncology reports},
  year={2012},
  volume={27 5},
  pages={1407-12}
}
Widdrol, a natural sesquiterpene present in Juniperus sp., has been shown to exert anticancer and antifungal effects. Emerging evidence has suggested that AMP-activated protein kinase (AMPK), which functions as a cellular energy sensor, is a potential therapeutic target for human cancers. In this study, we found that AMPK mediates the anticancer effects of widdrol through induction of apoptosis in HT-29 colon cancer cells. We showed… CONTINUE READING

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Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2011

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