Why ultra high performance liquid chromatography produces more tailing peaks than high performance liquid chromatography, why it does not matter and how it can be addressed.

Abstract

The purpose of this study is to demonstrate, with experiments and with computer simulations based on a firm chromatographic theory, that the wide spread perception of that the United States Pharmacopeia tailing factor must be lower than 2 (T(f)<2) is questionable when using the latest generation of LC equipment. It is shown that highly efficient LC… (More)
DOI: 10.1016/j.chroma.2011.08.018

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Cite this paper

@article{Petersson2011WhyUH, title={Why ultra high performance liquid chromatography produces more tailing peaks than high performance liquid chromatography, why it does not matter and how it can be addressed.}, author={Patrik Petersson and Patrik Forss{\'e}n and Lena Edstr{\"o}m and Farzad Samie and Stephen Tatterton and Adrian K. Clarke and Torgny Fornstedt}, journal={Journal of chromatography. A}, year={2011}, volume={1218 39}, pages={6914-21} }