• DOI:10.1152/PHYSIOL.00006.2004
Corpus ID: 17844506

Why trypanosomes cause sleeping sickness.

@article{Lundkvist2004WhyTC,
  title={Why trypanosomes cause sleeping sickness.},
  author={G. Lundkvist and K. Kristensson and M. Bentivoglio},
  journal={Physiology},
  year={2004},
  volume={19},
  pages={
          198-206
        }
}

G. Lundkvist, K. Kristensson, M. Bentivoglio

Published 2004

Biology, Medicine

Physiology

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African trypanosomiasis or sleeping sickness is hallmarked by sleep and wakefulness disturbances. In contrast to other infections, there is no hypersomnia, but the sleep pattern is fragmented. This overview discusses that the causative agents, the parasites Trypanosoma brucei, target circumventricular organs in the brain, causing inflammatory responses in hypothalamic structures that may lead to dysfunctions in the circadian-timing and sleep-regulatory systems.