Why toxic equivalency factors are not suitable for perfluoroalkyl chemicals.

@article{Peters2011WhyTE,
  title={Why toxic equivalency factors are not suitable for perfluoroalkyl chemicals.},
  author={Jeffrey M. Peters and Frank J. Gonzalez},
  journal={Chemical research in toxicology},
  year={2011},
  volume={24 10},
  pages={1601-9}
}
The pervasive nature of perfluoroalkyl chemicals in the environment has generated considerable interest for developing new strategies for risk assessment. In experimental animal models, exposure to perfluoroalkyl chemicals can cause developmental toxicity and hepatotoxicity. Peroxisome proliferator-activated receptor-α (PPARα) is required to mediate some but not all of these effects. Since PPARα has a role in mediating some of these effects, and there is some overlap in the type of toxicities… CONTINUE READING

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