Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection.

@article{Courchesne2005WhyTF,
  title={Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection.},
  author={Eric Courchesne and Karen Pierce},
  journal={Current opinion in neurobiology},
  year={2005},
  volume={15 2},
  pages={225-30}
}
Although it has long been thought that frontal lobe abnormality must play an important part in generating the severe impairment in higher-order social, emotional and cognitive functions in autism, only recently have studies identified developmentally early frontal lobe defects. At the microscopic level, neuroinflammatory reactions involving glial activation, migration defects and excess cerebral neurogenesis and/or defective apoptosis might generate frontal neural pathology early in development… CONTINUE READING
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Decreased cell column spacing in autism [abstract

  • D Buxhoeveden, K Semendeferi, N Schenker, E Courchesne
  • Soc Neurosci
  • 2004
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