Why target apoptosis in cancer treatment?

  title={Why target apoptosis in cancer treatment?},
  author={Shailaja Kasibhatla and Ben Tseng},
  journal={Molecular cancer therapeutics},
  volume={2 6},
Defective apoptosis (programmed cell death) represents a major causative factor in the development and progression of cancer. The ability of tumor cells to evade engagement of apoptosis can play a significant role in their resistance to conventional therapeutic regimens. Our understanding of the complexities of apoptosis and the mechanisms evolved by tumor cells to resist engagement of cell death has focused research effort into the development of strategies designed to selectively induce… CONTINUE READING
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