• Corpus ID: 249017594

Why strengthening gap junctions may hinder action potential propagation

  title={Why strengthening gap junctions may hinder action potential propagation},
  author={Erin Munro Krull and Christoph Borgers},
. Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They connect cells throughout the body, including heart myocytes, neurons, and astrocytes. Propagation mediated by gap junctions can be passive or active . In passive propagation, the mem- brane potential of one cell influences that of neighboring cells without triggering action potentials (APs). In active propagation, an AP in one cell triggers APs in neighboring cells; this occurs in cardiac tissue and… 


Conduction in cardiac tissue. Historical reflections
These findings are strong arguments in favor of the gap junction thesis and do not exclude, as predicted by theoretical calculations, that in conditions of an abnormal fall in gap junction conductance ephaptic conduction takes over.
Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks
A model of the gap-junctional route for intercellular Ca2+ wave propagation in astrocytes is proposed and it is shown that long-distance regenerative signaling requires nonlinear coupling in the gap junctions, and short-distance Regenerative signaling is favored when the internalCa2+ dynamics implements frequency modulation-encoding oscillations with pulsating dynamics.
Gap junctions and propagation of the cardiac action potential.
This chapter traces the path of the action potential from its generation in the sinus node to propagation through the working myocardium, with a detailed discussion of the role of gap junctions.
Role of gap junctions in the propagation of the cardiac action potential.
  • S. Rohr
  • Biology
    Cardiovascular research
  • 2004
Subthreshold somatic voltage in neocortical pyramidal cells can control whether spikes propagate from the axonal plexus to axon terminals: a model study.
This work constrains the density of gap junctions on collaterals in the model and suggests that axonal sprouting due to cortical lesions may result in abnormally high gap junction density onCollaterals, leading in turn to excessive VFO activity and hence to epilepsy via kindling.
Neurotransmitters and gap junctions in developing neural circuits
Intercellular calcium waves in the fire-diffuse-fire framework: Green's function for gap-junctional coupling.
A simple, yet biophysically realistic model for the propagation of intercellular calcium waves based on the fire-diffuse-fire type model for calcium dynamics is introduced and the "sum-over-trips" formalism is developed that takes into account the boundary conditions at gap junctions providing a generalization of the original sum-over thetrips approach for constructing the response function for branched neural dendrites.
Propagating Activity in Neocortex, Mediated by Gap Junctions and Modulated by Extracellular Potassium
The propagating unit activity was unaffected by blockade of GABAergic synaptic transmission, but it was modulated by glutamatergic blockers, and was reduced, and in most cases prevented altogether, by pharmacological blockade of gap junctions.