Why sources of heterogeneity in meta-analysis should be investigated.

@article{Thompson1994WhySO,
  title={Why sources of heterogeneity in meta-analysis should be investigated.},
  author={Simon Giles Thompson},
  journal={BMJ},
  year={1994},
  volume={309 6965},
  pages={1351-5}
}
Although meta-analysis is now well established as a method of reviewing evidence, an uncritical use of the technique can be very misleading. One common problem is the failure to investigate appropriately the sources of heterogeneity, in particular the clinical differences between the studies included. This paper distinguishes between the concepts of clinical and statistical heterogeneity and exemplifies the importance of investigating heterogeneity by using published meta-analyses of… CONTINUE READING
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