Why sleep is important for health: a psychoneuroimmunology perspective.

@article{Irwin2015WhySI,
  title={Why sleep is important for health: a psychoneuroimmunology perspective.},
  author={Michael R. Irwin},
  journal={Annual review of psychology},
  year={2015},
  volume={66},
  pages={
          143-72
        }
}
  • M. Irwin
  • Published 5 January 2015
  • Medicine, Psychology, Biology
  • Annual review of psychology
Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity… 

Tables from this paper

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity
TLDR
Interactions between sleep and inflammatory biology mechanisms underscore the implications of sleep disturbance for inflammatory disease risk, and provide a map to guide the development of treatments that modulate inflammation, improve sleep, and promote sleep health.
Role of sleep deprivation in immune-related disease risk and outcomes
TLDR
Recent advancements on the immune responses to sleep deprivation as evidenced by experimental and epidemiological studies, the pathophysiology, and the role for the sleep deprivation-induced immune changes in increasing the risk for chronic diseases are reviewed.
Sleep and inflammation: partners in sickness and in health
  • M. Irwin
  • Biology, Psychology
    Nature Reviews Immunology
  • 2019
TLDR
The current understanding of the relationship between sleep dynamics and host defence mechanisms is described, with a focus on cytokine responses, the neuroendocrine and autonomic pathways that connect sleep with the immune system and the role of inflammatory peptides in the homeostatic regulation of sleep.
The Sleep-Immune Crosstalk in Health and Disease
TLDR
The induction of a hormonal constellation that supports immune functions is one likely mechanism underlying the immune-supporting effects of sleep, and sleep appears to promote inflammatory homeostasis through effects on several inflammatory mediators, such as cytokines.
Role of Glia in the Regulation of Sleep in Health and Disease.
TLDR
The literature pertaining to the role of astrocytes and microglia in the regulation of sleep under normal physiological conditions and the beneficial and deleterious consequences of glia-mediated neuroinflammation, whether it is acute, or chronic and associated with brain diseases, are summarized.
Sleep and COVID-19: considerations about immunity, pathophysiology, and treatment
TLDR
A narrative review is conducted in to address the relationship between COVID-19 and sleep, as well as its immunological aspects and strategies that may be applied in order to mitigate the harmful effects on health that affects everyone during the pandemic.
Sleep Dysfunction in COVID-19 Patients: Prevalence, Risk Factors, Mechanisms, and Management
TLDR
The link between sleep deprivation, susceptibility to viral infections, and psychosocial wellbeing in relevance to COVID-19 is discussed and the existing evidence regarding the presence and role of sleep apnea in infected individuals is summarized.
Sleep, Sleep Disorders, and Immune Function
TLDR
One of the most common pediatric sleep disorders, namely, obstructive sleep apnea, is examined, and its intricate interactions with the immune system are illustrated.
Sleep and rheumatic diseases.
...
...

References

SHOWING 1-10 OF 203 REFERENCES
Sleep and Immunity
TLDR
It is suggested that the immune system plays a role in the relationship between sleep and health and that sleep processes and immunity show bidirectional interactions, as evidenced in both animal and human studies.
Experimental Immunomodulation, Sleep, and Sleepiness in Humans
TLDR
Preliminary evidence from human studies suggesting that inflammatory cytokines such as TNF‐α not only mediate altered sleep‐wake behavior during infections, but in addition are involved in physiological sleep regulation and in hypnotic effects of established sedating drugs.
Depressive disorders and immunity: 20 years of progress and discovery
Sleep Loss Activates Cellular Inflammatory Signaling
Sleep, sleep deprivation and infectious disease: studies in animals.
  • L. Toth
  • Biology, Psychology
    Advances in neuroimmunology
  • 1995
How (and why) the immune system makes us sleep
TLDR
It is proposed that the alterations in sleep architecture during infection are exquisitely tailored to support the generation of fever, which in turn imparts survival value.
Sleep after Vaccination Boosts Immunological Memory
TLDR
Novel evidence is provided that sleep promotes human Th1 immune responses, implicating a critical role for slow-wave sleep in this process, and like the nervous system, the immune system takes advantage of the offline conditions during sleep to foster adaptive immune responses resulting in improved immunological memory.
Hyperarousal and insomnia: state of the science.
Sleep loss and hypertension: a systematic review.
TLDR
This analysis shows that experimental sleep deprivation, short sleep duration, and persistent insomnia are associated with increased blood pressure and increased risk of hypertension, even after controlling for other risk factors.
...
...