Why optimal states recruit fewer reactions in metabolic networks

@inproceedings{Lee2012WhyOS,
  title={Why optimal states recruit fewer reactions in metabolic networks},
  author={Joo sang Lee and Takashi Nishikawa and Adilson E. Motter},
  year={2012}
}
  • Joo sang Lee, Takashi Nishikawa, Adilson E. Motter
  • Published 2012
  • Biology, Physics, Mathematics
  • The metabolic network of a living cell involves several hundreds or thousands of interconnected biochemical reactions. Previous research has shown that under realistic conditions only a fraction of these reactions is concurrently active in any given cell. This is partially determined by nutrient availability, but is also strongly dependent on the metabolic function and network structure. Here, we establish rigorous bounds showing that the fraction of active reactions is smaller (rather than… CONTINUE READING

    Figures and Tables from this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES

    Dispensability of Escherichia coli's latent pathways.

    VIEW 2 EXCERPTS

    Improved network performance via antagonism: From synthetic rescues to multi-drug combinations

    • Adilson E. Motter
    • Biology, Physics, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2010
    VIEW 1 EXCERPT

    Spontaneous Reaction Silencing in Metabolic Optimization

    VIEW 2 EXCERPTS

    Global reconstruction of the human metabolic network based on genomic and bibliomic data.

    VIEW 1 EXCERPT