Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials.

@article{Moncla2005WhyNM,
  title={Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials.},
  author={Bernard J. Moncla and Sharon Louise Hillier},
  journal={Sexually transmitted diseases},
  year={2005},
  volume={32 8},
  pages={491-4}
}
OBJECTIVES To understand why clinical trials failed to demonstrate efficacy of nonoxynol-9 in preventing gonorrhea. GOAL To test the hypothesis that nonoyxnol-9 failed to prevent acquisition of Neisseria gonorrhoeae because most isolates are resistant to killing by nonoyxnol-9 at the level attainable with intravaginal use. STUDY The lowest concentrations of nonoxynol-9 required to kill or inhibit growth of clinical isolates of N gonorrhoeae and Lactobacillus were determined. RESULTS Most… CONTINUE READING

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