Why nature chose phosphate to modify proteins.

  • Tony Hunter
  • Published 2012 in
    Philosophical transactions of the Royal Society…


The advantageous chemical properties of the phosphate ester linkage were exploited early in evolution to generate the phosphate diester linkages that join neighbouring bases in RNA and DNA (Westheimer 1987 Science 235, 1173-1178). Following the fixation of the genetic code, another use for phosphate ester modification was found, namely reversible… (More)
DOI: 10.1098/rstb.2012.0013


Cite this paper

@article{Hunter2012WhyNC, title={Why nature chose phosphate to modify proteins.}, author={Tony Hunter}, journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, year={2012}, volume={367 1602}, pages={2513-6} }