Why model?

@article{Wolkenhauer2014WhyM,
  title={Why model?},
  author={O. Wolkenhauer},
  journal={Frontiers in Physiology},
  year={2014},
  volume={5}
}
Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why… Expand
355 Citations
Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways
  • 2
  • PDF
Answering evolutionary questions: A guide for mechanistic biologists
  • J. Masel, D. Promislow
  • Mathematics, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2016
  • 8
  • PDF
Multiscale Solutions to Quantitative Systems Biology Models
  • 1
Using optimal control to understand complex metabolic pathways
  • 1
  • PDF
Automated Extension of Cell Signaling Models with Genetic Algorithm
  • 5
Respectful Modeling: Addressing Uncertainty in Dynamic System Models for Molecular Biology.
  • 16
  • PDF
Stochastic simulation in systems biology
  • 78
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Conceptualizing a tool to optimize therapy based on dynamic heterogeneity.
  • 20
  • PDF
The search for organizing principles as a cure against reductionism in systems medicine
  • 55
The road from systems biology to systems medicine
  • 78
  • PDF
Stochastic approaches in systems biology
  • M. Ullah, O. Wolkenhauer
  • Computer Science, Medicine
  • Wiley interdisciplinary reviews. Systems biology and medicine
  • 2010
  • 87
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs
  • 67
  • PDF
Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies
  • 99
  • PDF
The music of life : biology beyond genes
  • 291
...
1
2
3
...