Why kidneys fail in autosomal dominant polycystic kidney disease

@article{Grantham2011WhyKF,
  title={Why kidneys fail in autosomal dominant polycystic kidney disease},
  author={J. J. Grantham and Sumanth Mulamalla and Katherine I Swenson-Fields},
  journal={Nature Reviews Nephrology},
  year={2011},
  volume={7},
  pages={556-566}
}
The weight of evidence gathered from studies in humans with hereditary polycystic kidney disease (PKD)1 and PKD2 disorders, as well as from experimental animal models, indicates that cysts are primarily responsible for the decline in glomerular filtration rate that occurs fairly late in the course of the disease. The processes underlying this decline… CONTINUE READING