Why it is crucial to analyze non clonal chromosome aberrations or NCCAs?

@inproceedings{Heng2016WhyII,
  title={Why it is crucial to analyze non clonal chromosome aberrations or NCCAs?},
  author={Henry H Heng and Sarah M. Regan and Guo Liu and Christine J. Ye},
  booktitle={Molecular Cytogenetics},
  year={2016}
}
Current cytogenetics has largely focused its efforts on the identification of recurrent karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale of doing so seems simple: recurrent genetic changes are relevant for diseases or specific physiological conditions, while non clonal chromosome aberrations (NCCAs) are insignificant genetic background or noise. However, in reality, the vast majority of chromosomal alterations are NCCAs, and it is challenging to… CONTINUE READING

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Cancer Cytogenetics

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