Why is uncompetitive inhibition so rare?

@article{CornishBowden1986WhyIU,
  title={Why is uncompetitive inhibition so rare?},
  author={Athel Cornish-Bowden},
  journal={FEBS Letters},
  year={1986},
  volume={203}
}

Enzyme Inhibition in Open Systems

Investigations of the open system behavior of reversible dead-end inhibitors indicated that substrate-competitive inhibition may often be an inappropriate basis for design of potential therapeutic agents, and chemical analogs of pathogen-specific enzymic reaction products rather than analogS of substrates provide a promising basis for the systematic design of such uncompetitive inhibitors.

Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.

Kinetic analysis for wild type and mutant protease showed mixed-type competitive-uncompetitive inhibition for darunavir and the chemically related amprenavir, while saquinavir showed competitive inhibition.

Side chain interactions at the dimer interface of Vibrio alkaline phosphatase determine its reactivity, stability and desthiobiotin inhibition

This study assessed a possible inhibition of desthiobiotin (DDB) on VAP, which is used to elute purified enzyme samples of Strep-Tactin® affinity columns and is likely of a mixed noncompetitive nature.

Basic models for differential inhibition of enzymes.

Kinetic Studies for the Inhibition Effect of Pentachlorophenol on Alkaline Phosphatase Activity In Vitro

The inhibition kinetic parameters of pentachlorophenol on bovine intestinal mucosa alkaline phosphatase (ALP) activity were studied by spectrophotometry and indicated that the nature of the inhibition was of an uncompetitive type.

Properties Needed for the Enzymes of an Interconvertible Cascade to Generate a Highly Sensitive Response

The understanding of the mechanisms that allow a high degree of sensitivity should constitute a major goal of any theory of metabolic control, as the sensitivity of the pathway to the effector is decreased accordingly.

The Basic Mechanisms of Inhibition and Nonessential Activation

This chapter discusses representative examples that span several branches of the biological sciences and discusses substrates and reaction products in the role of modifiers within the mechanisms to which they belong.

Teaching Enzyme Kinetics and Mechanism in the 21 st Century

The teaching of enzyme kinetics has been neglected in recent years, with the growth in influence of molecular biology, but its importance has not diminished and it has become clear that it has to be combined with stoicheiometric analysis, knowledge of metabolic networks and analysis of enzyme regulation.
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