Why is the high grade inhibition of gastric acid secretion afforded by proton pump inhibitors often required for healing of reflux esophagitis? An epithelial perspective.

Abstract

The effectiveness of proton pump inhibitors in the treatment of reflux esophagitis is undisputed. The same is true for the mechanism by which their beneficial effects are achieved and, that is, by potent suppression of gastric acid secretion. The underappreciated side of the story is not that potent acid suppression controls the disease but why in fact such… (More)

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@article{Orlando1996WhyIT, title={Why is the high grade inhibition of gastric acid secretion afforded by proton pump inhibitors often required for healing of reflux esophagitis? An epithelial perspective.}, author={Rosanna Orlando}, journal={The American journal of gastroenterology}, year={1996}, volume={91 9}, pages={1692-6} }