Why is the centromere so cold?

  • K. Choo
  • Published 1998 in Genome research


Chromosomes are known to contain local hot and cold spots that undergo quite different rates of meiotic recombination. The question of why such regional variation in recombination rates exists on chromosomes holds a strange mix of intrigue and frustration for geneticists. One of the human chromosomes that has been carefully studied over the years in this… (More)