Why is coeliac disease endemic in the people of the Sahara?

@article{Catassi1999WhyIC,
  title={Why is coeliac disease endemic in the people of the Sahara?},
  author={Carlo Catassi and I M Ratsch and Lenora Gandolfi and Riccardo Pratesi and Elisabetta Fabiani and Ramzi El Asmar and Maria Frijia and Italo Bearzi and L Vizzoni},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={647-648}
}
The prevalence of antiendomysial antibody (AEA) in 989 Saharawi children was 5.6%. Intestinal biopsies in a subsample confirmed that AEA is a marker of coellac disease in people living in a developing country. 
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References

SHOWING 1-5 OF 5 REFERENCES
Anti-reticulin antibodies: useful adjunct to histopathology in diagnosing celiac disease, especially in a developing country.
TLDR
A positive ARA assay with an initial subtotal villous atrophy was seen to always suggest CD, and these together would provide a useful basis for instituting gluten-free diets in suspected cases of CD rather than histological findings alone. Expand
Chronic diarrhea and malnutrition--histology of the small intestinal lesion.
TLDR
The jejunal lesion in Gambian children with chronic diarrhea-malnutrition syndrome is consistent with an intestinal reaction to some environmental antigen of the cell-mediated type, strengthened by the expression of major histocompatibility class 2D locus alloantigens on crypt epithelial cells in the absence of gut-reactive autoantibodies. Expand
Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease.
TLDR
Calcium-activated tissue transglutaminase autoantibody ELISA is highly accurate in detecting untreated celiac disease and seems to be the target self-antigen for endomysial antibodies. Expand
Expression of receptors for enterotoxigenic Escherichia coli during enterocytic differentiation of human polarized intestinal epithelial cells in culture
TLDR
Both in HT-29 cells (HT-29 Glc-/+) and in Caco-2 cells cultured under standard conditions, ETEC CFA receptors develop as a function of day in culture, indicating that the expression of the ETECCFA receptors was a growth-related event. Expand