Why is chitosan mucoadhesive?

@article{Sogias2008WhyIC,
  title={Why is chitosan mucoadhesive?},
  author={Ioannis A Sogias and Adrian C. Williams and Vitaliy V Khutoryanskiy},
  journal={Biomacromolecules},
  year={2008},
  volume={9 7},
  pages={1837-42}
}
Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at pH < 6.5. It has been widely used for developing drug delivery systems because of its excellent mucoadhesive properties. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains poorly defined. Here, we have examined the role of primary amino groups and the role of electrostatic attraction, hydrogen bonding, and… CONTINUE READING
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