Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.

Abstract

Transthyretin (TTR) is one of the known human amyloidogenic proteins. Its native state is a homotetramer with each monomer having a beta-sandwich structure. Strong experimental evidence suggests that TTR dissociates into monomeric intermediates and that the monomers subsequently self-assemble to form amyloid deposits and insoluble fibrils. However, details… (More)

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Cite this paper

@article{Yang2003WhyIL, title={Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.}, author={Mingfeng Yang and Ming Lei and Shuanghong Huo}, journal={Protein science : a publication of the Protein Society}, year={2003}, volume={12 6}, pages={1222-31} }