Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.

@article{Yang2003WhyIL,
  title={Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.},
  author={Mingfeng Yang and Ming Lei and Shuanghong Huo},
  journal={Protein science : a publication of the Protein Society},
  year={2003},
  volume={12 6},
  pages={1222-31}
}
Transthyretin (TTR) is one of the known human amyloidogenic proteins. Its native state is a homotetramer with each monomer having a beta-sandwich structure. Strong experimental evidence suggests that TTR dissociates into monomeric intermediates and that the monomers subsequently self-assemble to form amyloid deposits and insoluble fibrils. However, details… CONTINUE READING