Why hydroxy-proline improves the catalytic power of the peptidoglycan N-deacetylase enzyme: insight from theory.

@article{Prejan2019WhyHI,
  title={Why hydroxy-proline improves the catalytic power of the peptidoglycan N-deacetylase enzyme: insight from theory.},
  author={Mario Prejan{\`o} and I. Romeo and Luigi Sgrizzi and N. Russo and T. Marino},
  journal={Physical chemistry chemical physics : PCCP},
  year={2019}
}
  • Mario Prejanò, I. Romeo, +2 authors T. Marino
  • Published 2019
  • Medicine, Chemistry
  • Physical chemistry chemical physics : PCCP
  • Nature exploits different strategies for enhancing the catalytic activity of enzymes, often resorting to producing beneficial mutations. The case of post-translational proline hydroxylation mutation in the active site of polysaccharide deacetylase (PDA) Bc1960 from Bacillus cereus is an interesting example of how small chemical modifications can cause significant improvements in enzymatic activity. In the present study the deacetylation mechanism promoted by both OH-proline (2Hyp) and standard… CONTINUE READING
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