Why human anti-Galα1-4Galβ1-4Glc natural antibodies do not recognize the trisaccharide on erythrocyte membrane? Molecular dynamics and immunochemical investigation.

@article{Volynsky2017WhyHA,
  title={Why human anti-Galα1-4Galβ1-4Glc natural antibodies do not recognize the trisaccharide on erythrocyte membrane? Molecular dynamics and immunochemical investigation.},
  author={Pavel E. Volynsky and Roman G. Efremov and Ilya Mikhalev and Kira L. Dobrochaeva and Alexander B. Tuzikov and Elena Yu Korchagina and Polina Obukhova and Evgenia Rapoport and Nicolai V. Bovin},
  journal={Molecular immunology},
  year={2017},
  volume={90},
  pages={87-97}
}
BACKGROUND Human blood contains a big variety of natural antibodies, circulating throughout life at constant concentration. Previously, we have found natural antibodies capable of binding to trisaccharide Galα1-4Galβ1-4Glc (Pk) practically in all humans. Intriguingly, the same trisaccharide is a key fragment of glycosphingolipid globotriaosylceramide… CONTINUE READING