Why hasn’t there been more progress in new Chagas disease drug discovery?

  title={Why hasn’t there been more progress in new Chagas disease drug discovery?},
  author={Alane Beatriz Vermelho and Giseli Capaci Rodrigues and Claudiu T. Supuran},
  journal={Expert Opinion on Drug Discovery},
  pages={145 - 158}
ABSTRACT Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the 1960s with the same two drugs, benznidazole and nifurtimox, still in use. The complex life cycle, genetic diversity of T. cruzi strains, different sensitivities to the available drugs, as well as little interest from pharmaceutical companies and inadequate methodologies for translating in vitro and in vivo… Expand
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