Why genes in pieces?

  title={Why genes in pieces?},
  author={Walter Gilbert},
  • W. Gilbert
  • Published 9 February 1978
  • Biology, Medicine
  • Nature
The development of mechanistic enzymology in the 20th century.
  • T. Bugg
  • Chemistry, Medicine
    Natural product reports
  • 2001
The Concept of Biological Activity and Its Application to Biological Phenomena
The origin of life is discussed from the aspect of biological activity and the extended view of evolution, and a new thermodynamic quantity of Biological activity is proposed for characterizing the state of an organism in terms of acquired energy, stored energy and systematization.
Changing images of the gene.
Gene expression and genetic engineering in the lens. Friedenwald lecture.
Of particular interest was that a group of specialized proteins (crystallins) could be recognized as markers for specific gene expression during lens differentiation, and that traveling this path would consider, simultaneously, evolutionary and developmental time scales.
The modern period of gene conceptualization, wherein none of the classical or neoclassical criteria are sufficient to define a gene, is left with a rather abstract, open, and generalized concept of the gene.
Preparation of Bifunctional Enzyme Complexes by Fusion of Two Genes a
Several immobilization experiments with other enzyme sequences have been reported, all of which suggest that the favorable effects of an immobilized over a soluble system are due to enzyme proximity and/or diffusional consideration.
The genes of Na, K-ATPase, a selfreview
The review is devoted to analysis of research carried out in the author's laboratory on structure-function relationships in genes coding for Na, K-ATPases. Also considered are problems related to


Spliced segments at the 5′ terminus of adenovirus 2 late mRNA*
Four segments of viral RNA may be joined together during the synthesis of mature hexon mRNA, a model is presented for adenovirus late mRNA synthesis that involves multiple splicing during maturation of a larger precursor nuclear RNA.
Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.
The 5'-terminal 100-200 ribonucleotides of late simian virus 40 (SV40) mRNAs are not transcribed immediately adjacent to their coding sequences, implying a novel mechanism for biosynthesis of SV40 mRNA.
Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart.
  • C. Brack, S. Tonegawa
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1977
Electron microscopy of R-loops formed between the cloned DNA and purified lambda chain mRNA (HOPC 2020) revealed that the Vlambda and Clambda DNA sequences are separated by a 1250-base DNA fragment.
The presence of ovalbumin mRNA coding sequences in multiple restriction fragments of chicken DNA.
Chicken DNA has been digested with restriction enzymes and the size distribution of the DNA fragments containing ovalbumin specific sequences has been examined after separation of the fragments on
Ovalbumin gene is split in chicken DNA
The ovalbumin gene is split in chicken DNA. Two interruptions in the sequences coding for ovalbumin mRNA have been detected, at least one of them lying in the protein coding sequence. The unexpected