Why genes in pieces?

@article{Gilbert1978WhyGI,
  title={Why genes in pieces?},
  author={Walter Gilbert},
  journal={Nature},
  year={1978},
  volume={271},
  pages={501-501}
}
  • W. Gilbert
  • Published 9 February 1978
  • Biology, Medicine
  • Nature
The development of mechanistic enzymology in the 20th century.
  • T. Bugg
  • Chemistry, Medicine
    Natural product reports
  • 2001
The Concept of Biological Activity and Its Application to Biological Phenomena
TLDR
The origin of life is discussed from the aspect of biological activity and the extended view of evolution, and a new thermodynamic quantity of Biological activity is proposed for characterizing the state of an organism in terms of acquired energy, stored energy and systematization.
Changing images of the gene.
Gene expression and genetic engineering in the lens. Friedenwald lecture.
TLDR
Of particular interest was that a group of specialized proteins (crystallins) could be recognized as markers for specific gene expression during lens differentiation, and that traveling this path would consider, simultaneously, evolutionary and developmental time scales.
THE QUARTERLY REVIEW of BJIOLOGY
TLDR
The modern period of gene conceptualization, wherein none of the classical or neoclassical criteria are sufficient to define a gene, is left with a rather abstract, open, and generalized concept of the gene.
Preparation of Bifunctional Enzyme Complexes by Fusion of Two Genes a
TLDR
Several immobilization experiments with other enzyme sequences have been reported, all of which suggest that the favorable effects of an immobilized over a soluble system are due to enzyme proximity and/or diffusional consideration.
The genes of Na, K-ATPase, a selfreview
The review is devoted to analysis of research carried out in the author's laboratory on structure-function relationships in genes coding for Na, K-ATPases. Also considered are problems related to
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