Why genes in pieces?

@article{Gilbert1978WhyGI,
  title={Why genes in pieces?},
  author={Walter Gilbert},
  journal={Nature},
  year={1978},
  volume={271},
  pages={501-501}
}
The Concept of Biological Activity and Its Application to Biological Phenomena
TLDR
The origin of life is discussed from the aspect of biological activity and the extended view of evolution, and a new thermodynamic quantity of Biological activity is proposed for characterizing the state of an organism in terms of acquired energy, stored energy and systematization. Expand
Analog-digital molecular cell computer.
TLDR
The living cell is controlled by a molecular stochastic computer of parallel-successive action which may be equivalent to the universal computer, and cyclic nucleotides are intraneuron membrane potential controlling systems which can be described as molecular diffusional analog computers. Expand
The development of mechanistic enzymology in the 20th century.
  • T. Bugg
  • Chemistry, Medicine
  • Natural product reports
  • 2001
Changing images of the gene.
TLDR
This overview highlights some of the historical milestones that contributed to the development of the image of the gene, extending elements of issues laid down by Rédei (2003). Expand
Gene expression and genetic engineering in the lens. Friedenwald lecture.
  • J. Piatigorsky
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1987
TLDR
Of particular interest was that a group of specialized proteins (crystallins) could be recognized as markers for specific gene expression during lens differentiation, and that traveling this path would consider, simultaneously, evolutionary and developmental time scales. Expand
Advances in Na+,K+‐ATPase studies: from protein to gene and back to protein
TLDR
The results obtained have become the basis for the experiments which prove the existence of the earlier unknown αIII isoform of the Na+,K+‐ATPase catalytic subunit and have made possible the study of its function. Expand
MITOCHONDRIAL BIOGENESIS: EVOLUTION AND REGULATION
TLDR
The mt genophore in Saccharomyces is unusual in several respects, among them i) an unusually large proportion and length of AT-rich sequences, ii) non-contiguity of genes for rRNA precursors, and iii) the simultaneous presence of genes exhibiting both a pro- and a eucaryotic pattern of sequence organization. Expand
THE QUARTERLY REVIEW of BJIOLOGY
TLDR
The modern period of gene conceptualization, wherein none of the classical or neoclassical criteria are sufficient to define a gene, is left with a rather abstract, open, and generalized concept of the gene. Expand
Preparation of Bifunctional Enzyme Complexes by Fusion of Two Genes a
TLDR
Several immobilization experiments with other enzyme sequences have been reported, all of which suggest that the favorable effects of an immobilized over a soluble system are due to enzyme proximity and/or diffusional consideration. Expand
The genes of Na, K-ATPase, a selfreview
The review is devoted to analysis of research carried out in the author's laboratory on structure-function relationships in genes coding for Na, K-ATPases. Also considered are problems related toExpand
...
1
2
3
4
5
...

References

SHOWING 1-7 OF 7 REFERENCES
Spliced segments at the 5′ terminus of adenovirus 2 late mRNA*
TLDR
Four segments of viral RNA may be joined together during the synthesis of mature hexon mRNA, a model is presented for adenovirus late mRNA synthesis that involves multiple splicing during maturation of a larger precursor nuclear RNA. Expand
Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.
TLDR
The 5'-terminal 100-200 ribonucleotides of late simian virus 40 (SV40) mRNAs are not transcribed immediately adjacent to their coding sequences, implying a novel mechanism for biosynthesis of SV40 mRNA. Expand
The rabbit β-globin gene contains a large insert in the coding sequence
TLDR
The insert appears to be a general property of the rabbit β-globin gene, even in tissues in which this gene is active, which suggests that the insert is not involved in inactivating the gene in nonerythroid tissues. Expand
Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart.
  • C. Brack, S. Tonegawa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1977
TLDR
Electron microscopy of R-loops formed between the cloned DNA and purified lambda chain mRNA (HOPC 2020) revealed that the Vlambda and Clambda DNA sequences are separated by a 1250-base DNA fragment. Expand
The presence of ovalbumin mRNA coding sequences in multiple restriction fragments of chicken DNA.
Chicken DNA has been digested with restriction enzymes and the size distribution of the DNA fragments containing ovalbumin specific sequences has been examined after separation of the fragments onExpand
Ovalbumin gene is split in chicken DNA
The ovalbumin gene is split in chicken DNA. Two interruptions in the sequences coding for ovalbumin mRNA have been detected, at least one of them lying in the protein coding sequence. The unexpectedExpand