Why does the brain (not) have glycogen?

  title={Why does the brain (not) have glycogen?},
  author={Mauro DiNuzzo and Bruno Maraviglia and Federico Giove},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={33 5},
In the present paper we formulate the hypothesis that brain glycogen is a critical determinant in the modulation of carbohydrate supply at the cellular level. Specifically, we propose that mobilization of astrocytic glycogen after an increase in AMP levels during enhanced neuronal activity controls the concentration of glucose phosphates in astrocytes. This would result in modulation of glucose phosphorylation by hexokinase and upstream cell glucose uptake. This mechanism would favor glucose… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 80 references

Similar Papers

Loading similar papers…