Why does oestrogen-only hormone therapy have such a small impact on breast cancer risk? A hypothesis.

@article{Eden2011WhyDO,
  title={Why does oestrogen-only hormone therapy have such a small impact on breast cancer risk? A hypothesis.},
  author={John A Eden},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={2011},
  volume={27 3},
  pages={170-5}
}
There seems to be irrefutable evidence that oestrogen is involved in the pathogenesis of breast cancer. The disease mostly affects women and the epidemiology of breast cancer relates to reproductive markers such as pregnancy, age at menarche and age of menopause. Most breast cancers elaborate oestrogen receptors (ER) and in such cases endocrine therapies such as tamoxifen and aromatase-inhibitors (AIs) are effective adjuvant treatments. However, high-quality randomised controlled trials (RCTs… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…