Why does clozapine stimulate the motor activity of reserpine-pretreated rats when combined with a dopamine D1 receptor agonist?

@article{Jackson1995WhyDC,
  title={Why does clozapine stimulate the motor activity of reserpine-pretreated rats when combined with a dopamine D1 receptor agonist?},
  author={David M. Jackson and Nina Mohell and Annelie Bengtsson and Asa Malmberg},
  journal={European journal of pharmacology},
  year={1995},
  volume={282 1-3},
  pages={137-44}
}
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, clozapine, in rats depleted of their dopamine by reserpine and alpha-methyl-p-tyrosine pretreatment. Clozapine itself induced a slight but never significant stimulation of locomotor activity which was enhanced by the addition of the selective dopamine D1 receptor agonist, SKF38393 (2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- benzazepine), but not by the selective… CONTINUE READING

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AminesNo subtypemonoamine
The indirectly acting sympathomimetic amine , d - amphetamine , was inactive in the monoamine - depleted rats , indicating that no dopamine was available for release by d - amphetamine .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
However , the scopolamine plus SKF38393-induced stimulation was partially blocked by SCH23390 or by a combination of haloperidol and SCH23390 .
However , the scopolamine plus SKF38393-induced stimulation was partially blocked by SCH23390 or by a combination of haloperidol and SCH23390 .
A combination of SCH23390 and haloperidol blocked the clozapine plus SKF38393-induced locomotion .
A combination of SCH23390 and haloperidol blocked the clozapine plus SKF38393-induced locomotion .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
However , the scopolamine plus SKF38393-induced stimulation was partially blocked by SCH23390 or by a combination of haloperidol and SCH23390 .
However , the scopolamine plus SKF38393-induced stimulation was partially blocked by SCH23390 or by a combination of haloperidol and SCH23390 .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
Antipsychotic AgentsTherapeutic class ofClozapine
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The aim of the present experiments was to investigate the locomotor stimulant effects of the atypical antipsychotic agent , clozapine , in rats depleted of their dopamine by reserpine and alpha - methyl - p - tyrosine pretreatment .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
Clozapine itself induced a slight but never significant stimulation of locomotor activity which was enhanced by the addition of the selective dopamine D1 receptor agonist , SKF38393 ( 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- benzazepine ) , but not by the selective dopamine D2 receptor agonist , quinpirole .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
Clozapine itself induced a slight but never significant stimulation of locomotor activity which was enhanced by the addition of the selective dopamine D1 receptor agonist , SKF38393 ( 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- benzazepine ) , but not by the selective dopamine D2 receptor agonist , quinpirole .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
Clozapine itself induced a slight but never significant stimulation of locomotor activity which was enhanced by the addition of the selective dopamine D1 receptor agonist , SKF38393 ( 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- benzazepine ) , but not by the selective dopamine D2 receptor agonist , quinpirole .
The stimulation produced by clozapine plus SKF38393 was blocked by the selective dopamine D1 receptor antagonist , SCH23390 ( 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzapine hydrochloride ) , while the selective dopamine D2 receptor antagonist , haloperidol , was ineffective .
Clozapine itself induced a slight but never significant stimulation of locomotor activity which was enhanced by the addition of the selective dopamine D1 receptor agonist , SKF38393 ( 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- benzazepine ) , but not by the selective dopamine D2 receptor agonist , quinpirole .
The indirectly acting sympathomimetic amine , d - amphetamine , was inactive in the monoamine - depleted rats , indicating that no dopamine was available for release by d - amphetamine .
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