Why do we age?

@article{Kirkwood2000WhyDW,
  title={Why do we age?},
  author={Thomas B. L. Kirkwood and Steven N. Austad},
  journal={Nature},
  year={2000},
  volume={408},
  pages={233-238}
}
The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases. 

Genes that shape the course of ageing

  • T. Kirkwood
  • Biology
    Trends in Endocrinology & Metabolism
  • 2003

Ageing: The old worm turns more slowly

Detailed studies of cellular changes in ageing nematode worms show that they, like humans, suffer progressive muscle deterioration. Randomness of cell damage is another shared hallmark of the ageing

Ageing – Future Directions for Research in the Biology of Ageing

An increasing fraction of the world's population is living to an age when intrinsic biological constraints take their toll on health and quality of life through age-related frailty, as well as suffering from a wide range of age-associated disabilities and diseases.

Towards an e-biology of ageing: integrating theory and data

This work describes how a new web-based modelling initiative is seeking to integrate data and hypotheses from diverse biological sources that affect many tissues in an organism.

Evolution of ageing

  • T. Kirkwood
  • Biology
    Mechanisms of Ageing and Development
  • 2002

Understanding the Odd Science of Aging

The place of genetics in ageing research

Six experts present their opinions and comment on future directions in ageing research and how far is ageing controlled by the authors' genes.

Cancer and ageing: convergent and divergent mechanisms

The overall balance between these convergent and divergent mechanisms guarantees fitness and a cancer-free life until late adulthood for most individuals.

The aging-disease false dichotomy: understanding senescence as pathology

This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new, which underpins various erroneous traditional ideas about aging.
...

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