Why do two EF-Tu molecules act in the elongation cycle of protein biosynthesis?

Abstract

In the elongation cycle of bacterial protein biosynthesis, the binding of aminoacyl-tRNA (aa-tRNA) to the A-site of mRNA-programmed ribosomes is mediated by elongation factor Tu (EF-Tu) and associated with the hydrolysis of GTP. Recently, in the case of cognate aa-tRNA, the participation of two GTP molecules has been implicated in this reaction. These are… (More)

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Cite this paper

@article{Weijland1994WhyDT, title={Why do two EF-Tu molecules act in the elongation cycle of protein biosynthesis?}, author={Albert Weijland and Antonia Parmeggiani}, journal={Trends in biochemical sciences}, year={1994}, volume={19 5}, pages={188-93} }