Why do some intervertebral discs degenerate, when others (in the same spine) do not?

@article{Adams2015WhyDS,
  title={Why do some intervertebral discs degenerate, when others (in the same spine) do not?},
  author={M A Adams and Polly Lama and Uruj Zehra and Patricia Dolan},
  journal={Clinical anatomy},
  year={2015},
  volume={28 2},
  pages={195-204}
}
This review suggests why some discs degenerate rather than age normally. Intervertebral discs are avascular pads of fibrocartilage that allow movement between vertebral bodies. Human discs have a low cell density and a limited ability to adapt to mechanical demands. With increasing age, the matrix becomes yellowed, fibrous, and brittle, but if disc structure remains intact, there is little impairment in function, and minimal ingrowth of blood vessels or nerves. Approximately half of old lumbar… CONTINUE READING
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