Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method

@inproceedings{Tournier2011WhyDR,
  title={Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method},
  author={Benjamin B. Tournier and Caroline Chapusot and Emilie Courcet and Laurent Martin and C{\^o}me Lepage and Jean Faivre and F. Piard},
  booktitle={BMC Cancer},
  year={2011}
}
In colorectal carcinoma, extensive gene promoter hypermethylation is called the CpG island methylator phenotype (CIMP). Explaining why studies on CIMP and survival yield conflicting results is essential. Most experiments to measure DNA methylation rely on the sodium bisulfite conversion of unmethylated cytosines into uracils. No study has evaluated the performance of bisulfite conversion and methylation levels from matched cryo-preserved and Formalin-Fixed Paraffin Embedded (FFPE) samples using… CONTINUE READING
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