Why do lactobacilli dominate the human vaginal microbiota?

@article{Witkin2017WhyDL,
  title={Why do lactobacilli dominate the human vaginal microbiota?},
  author={Steven S Witkin and Iara Moreno Linhares},
  journal={BJOG : an international journal of obstetrics and gynaecology},
  year={2017},
  volume={124 4},
  pages={606-611}
}
Lactobacilli are the most abundant vaginal bacteria in women. They inhibit binding of other bacteria to epithelial cells and produce lactic acid that kills or inhibits the growth of many other bacteria. Lactic acid blocks histone deacetylases, thereby enhancing gene transcription and DNA repair. Lactic acid induces autophagy in epithelial cells to degrade intracellular microorganisms and promote homeostasis. Lactobacilli are tolerated by vaginal epithelial cells and inhibit induction of pro… CONTINUE READING
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