Why do hair cells and spiral ganglion neurons in the cochlea die during aging?

  title={Why do hair cells and spiral ganglion neurons in the cochlea die during aging?},
  author={Philip Perez and Jianxin Bao},
  journal={Aging and disease},
  volume={2 3},
Age-related decline of cochlear function is mainly due to the loss of hair cells and spiral ganglion neurons (SGNs). Recent findings clearly indicate that survival of these two cell types during aging depends on genetic and environmental interactions, and this relationship is seen at the systemic, tissue, cellular, and molecular levels. At cellular and molecular levels, age-related loss of hair cells and SGNs can occur independently, suggesting distinct mechanisms for the death of each during… CONTINUE READING
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