Why are there so many diverse replication machineries?

  title={Why are there so many diverse replication machineries?},
  author={Patrick Forterre},
  journal={Journal of molecular biology},
  volume={425 23},
The replicon model has initiated a major research line in molecular biology: the study of DNA replication mechanisms. Until now, the majority of studies have focused on a limited set of model organisms, mainly from Bacteria or Opisthokont eukaryotes (human, yeasts) and a few viral systems. However, molecular evolutionists have shown that the living world is more complex and diverse than believed when the operon model was proposed. Comparison of DNA replication proteins in the three domains… CONTINUE READING