Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia?

Abstract

It is well-known that heat-shock protein 70.1 (Hsp70.1), a major protein of the human Hsp70 family, plays cytoprotective roles by both its chaperone function and stabilization of lysosomal membranes. Recently, we found that calpain-mediated cleavage of carbonylated Hsp70.1 in the hippocampal cornu Ammonis1 (CA1) contributes to neuronal death after transient… (More)
DOI: 10.1111/j.1471-4159.2011.07550.x

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